Kinetic stability intelligence

Build biologic formulations that hold up under stress.

ARGEN delivers Kinetic Stability Intelligence through real-time measurement of aggregation onset, rate and molecular weight change under controlled stress.

Not sure whether ARGEN fits your stability question? Start with the five-minute assessment.

The ARGEN platform

See stability change as it happens.

ARGEN provides Kinetic Stability Intelligence by monitoring molecular weight change under controlled thermal, chemical and stirring stress.

Up to 8
samples compared in parallel
3 stress modes
thermal, chemical, and stirring
Real-time SLS
onset, rate, divergence, and Mw change
See the kinetic comparison
ARGEN benchtop static light scattering instrument
ARGEN benchtop static light scattering platform

Kinetic Stability Intelligence

Eight samples. One kinetic view.

Compare when samples start to change, how quickly they aggregate and which remain stable.

Four fast, two medium, two stable.

Illustrative 24-hour study | eight parallel samples | Mw(t)/M0

Data & methods

Loops automatically. Tap the chart to pause or resume; Enter or Space also works.

Illustrative simulation. Not measured data.Four fast, two medium and two stable samples reveal different paths over the same illustrative study. Schematic cells, not molecular simulation or imaging.

Workflow applications

Find your stability question.

Aggregation kinetics

Track aggregation onset, rate and molecular weight change.

Advanced modalities

Explore mAbs, proteins, peptides, RNA/LNPs and AAVs.

CRO/CDMO differentiation

Add stress ranking and kinetic evidence to client studies.

Industries and services

Built for pharma, food & beverage, and CRO/CDMO teams.

Pharma and biotech

Biologic formulation and developability teams

Compare biologic formulations with time-resolved SLS evidence.

Explore pharma and biotech

Food and beverage

Ingredient, flavor, and shelf-life R&D

Investigate processing stress, protein functionality, flavor stability and shelf-life questions.

Explore food & beverage

CRO/CDMO services

Add kinetic stability data to client programs

Give sponsors kinetic evidence for ranking and follow-up decisions.

Discuss CRO/CDMO fit

Research examples

Compare the response to stress.

Endpoint checks show the state at selected times. Continuous SLS adds onset, rate and divergence, helping focus follow-up with SEC, DLS, native PAGE and other established assays.

Stirring stress

Concentration under stirring stress

BSA | 25 °C | 500 rpm | 12 h

Data & methods

Loops automatically. Tap the chart to pause or resume; Enter or Space also works.

Chart reconstruction.Compare how the source-labeled BSA concentrations separate during stirring stress.

Temperature and pH

Temperature-dependent aggregation

mAb | 1 mg/mL | source range 50-80 °C | 8 selected traces

Data & methods

Loops automatically. Tap the chart to pause or resume; Enter or Space also works.

Chart reconstruction.Compare eight selected temperature-dependent traces, with source timing and known labels preserved.

pH-dependent molecular-weight change

BSA | 55 °C | logarithmic time in hours

Data & methods

Loops automatically. Tap the chart to pause or resume; Enter or Space also works.

Chart reconstruction.See how the three reported pH conditions change the molecular-weight response.

Workflow fit

From study question to next decision.

Choose the stress conditions, compare the kinetic paths and focus deeper characterization where it matters.

01

Frame the formulation question

Define candidates, stress conditions and the decision threshold.

02

Run parallel stress experiments

Compare up to eight samples under controlled stress.

03

Read the kinetic signal

Read onset, rate, divergence and molecular weight change.

04

Rank what moves forward

Prioritize orthogonal assays and support model validation.

Evaluation confidence

Test your material before you commit.

Choose representative material and a focused condition set. Review whether the kinetic evidence answers your study question before purchase.

  1. 01Use your material
  2. 02Target one decision
  3. 03Review fit before purchase
Request a sample evaluation

Kinetic stability resources

Choose your next step.

Interactive assessment

ARGEN Study-Fit Assessment

Check whether ARGEN fits your study before planning the experiment.

  • Formulation
  • Storage
  • Process stress
Run Fit Assessment

Method brief

Kinetic Stability Intelligence Brief

Review the method for one formulation or developability decision.

Get the brief
Cover of the Kinetic Stability Intelligence Brief

Studies & applications

Explore the evidence by topic.

Technical note

RNA stability monitoring

Thermal-stress RNA monitoring across buffer systems.

Read RNA note

Case study

rAAV capsid stability

Full and empty rAAV capsids under thermal stress.

Read rAAV study

Case study

Stirring stress aggregation

Concentration-dependent aggregation under stirring stress.

Read stirring study

Applications & service

Start with a practical ARGEN question.

Ask about applications, specifications, studies or service. The assistant uses approved ARGEN evidence and routes questions to the team when needed.

Ask ARGEN

Start discussion

Bring one real stability question.

Send a formulation, developability, process-stress, or service-fit question and we will point you to the most useful next step.

Your request is securely saved for follow-up and emailed to the ARGEN team. Do not include confidential molecule, formulation, patient, or proprietary program information. See the privacy note.

Prefer email? Contact Troy Sullivan.

View the ARGEN product page